Platelet Gel
Use of platelet-rich plasma to create a plastic and adhesive gel that can be used for local treatment of damaged tissue was examined for effect in management of radiodermatitis.
Plant Extract Cream (Capilen®)
Capilen® cream is a topical phytotherapic product that has been tested for its efficacy in the prevention and management of radiodermatitis.
Pimecrolimus
Pimecrolimus is a topical immunomodulating agent that decreases inflammation. It has been used to treat eczema and tested in patients with cancer for its effect on skin reactions to chemotherapy.
Pilocarpine
Pilocarpine is a cholinergic agonist. It works by increasing the amount of saliva in the mouth. It is used to treat dry mouth and mucositis caused by radiotherapy in people with head and neck cancer. Pilocarpine comes as a tablet to take by mouth.
Phenylbutyrate Mouthwash
Phenylbutarate is a chemical compound that is a type of gene modulator that can reduce oxidative stress induced tissue damage and is currently an approved drug for urea cycle disorder. A mouth rinse containing phenylbutarate was studied for its effects on mitigating oral mucositis in patients with cancer.
PG2
PG2 is an investigational drug extracted from Astragalus membranaceus, which appear to have an effect on the hematopoiesis system. PG2 was studied in patients with cancer for its effect on fatigue.
Petroleum-Based Topical Agents
Petroleum-based topical agents are chemical agents or ointments for application to the skin that contain a mixture of hydrocarbons, available as over-the-counter skin protectants. Petroleum-based products have been used in the management of skin reactions associated with cancer therapies.
Perioperative Drug Combinations
Researchers have assessed several drug combinations, administered in the preoperative and perioperative periods, in regard to management of the acute pain of patients with cancer. Drug combinations assessed include morphine + acetaminophen + ketoprofen + naproxen and acetaminophen + dexamethasone + dextromethorphan + celecoxib + gabapentin.
Pentoxifylline
Pentoxifylline is a methylxanthine derivative approved by the U.S. Food and Drug Administration for the treatment of intermittent claudication. It can inhibit tumor necrosis factor alpha production, reducing plasma levels of this cytokine, which is thought to be a mediator in cancer-associated anorexia and cachexia (Goldberg et al., 1995). Pentoxifylline was evaluated in anorexia.
Pentosan Polysulfate
Pentosan polysulfate is a medication that is similar to low-molecular-weight heparin, which has been used in the treatment of interstitial cystitis. In this condition, it reduces bladder pain, apparently by reducing irritation of the bladder wall. Pentosan polysulfate has been evaluated in patients with cancer for treatment of radiation-induced diarrhea.