Zinc/Zinc Supplements
Zinc is an essential trace element that has been associated with immune system function and has been used topically for the treatment of acne, burns, ulcers, and wounds. Zinc as a systemic dietary supplement and oral rinse has been evaluated in patients with cancer regarding its effect in the management of mucositis. As a topical treatment, zinc/zinc sulfate has been examined for the prevention and management of radiodermatitis.
Zolpidem
Classified as a sedative-hypnotic drug, zolpidem slows brain activity to allow sleep and is used to treat insomnia. It is taken once per day at bedtime. The drug is available as a generic and can be administered as a tablet by mouth, as a sublingual tablet, as an oral spray, and as an extended-release tablet.
Lymphatic Venous Anastomosis
One of the surgical techniques being examined for its effect on lymphedema development is lymphatic venous anastomosis. This involves the surgical creation of a local connection between the lymphatic vessels and veins in an attempt to facilitate drainage of lymphatic fluid into the circulatory system, thereby reducing lymphedema development.
Lubiprostone
Lubiprostone is a locally acting chloride channel activator with a similar mechanism of action to bulking agents and osmotic laxatives on intestinal fluid. Lubiprostone increases intestinal fluid volume and motility, resulting in stool softening and ease of passage. Although the U.S.
LSD-assisted Psychotherapy
Lysergic acid diethylamide (LSD) is a semisynthetic psychoactive compound initially used as an investigational drug for psychiatric research. In the 1950s, psychotherapy with psychedelic drugs such as LSD was used to induce a mystical experience with the aim of enabling individuals to work through difficult feelings and situations. LSD administration prior to individual psychotherapy recently was studied for its effect on anxiety.
Low Level Laser Therapy in Patients With Head and Neck Cancer
Low level laser therapy (LLLT) involves the use of a handheld infrared laser in an attempt to affect cells and physical symptoms often related to inflammation. This therapy has been approved by the U.S. Food and Drug Administration for treatment of post-mastectomy lymphedema. LLLT has also been evaluated for the prevention and treatment of mucositis in patients receiving stem cell transplantation conditioning or radiation therapy to the oral cavity area.
Low Level Laser Therapy in Patients Receiving Chemotherapy
Low-level laser therapy (LLLT) involves the use of a hand-held infrared laser in an attempt to affect cells and physical symptoms often related to inflammation. The therapy has been approved by the Food and Drug Administration for treatment of post-mastectomy lymphedema. LLLT has also been evaluated for prevention and treatment of mucositis.
Low Intensity Electrostatic Stimulation
Low-intensity electrostatic stimulation, or oscillation, is a therapeutic approach that consists in applying an intermittent electrostatic field of low intensity (U = 100–400 V; I = 150 μA) and extremely low frequency (30–200 Hz, rectangular, bi-phase) to the target area in patients with lymphedema to supplement manual lymphatic drainage.
Low Dose Methadone
Methadone is an opioid analgesic. Low-dose methadone begun at 2.5 mg daily and titrated up by 2.5 mg increments to a maximum daily dose of 15 mg was examined for effectiveness in patients with chronic pain.
Low-Dose Aspirin
Aspirin (acetylsalicylic acid) is a drug that has analgesic, anti-inflammatory, antipyretic properties and reduces platelet aggregation. Low-dose aspirin (100 mg per day) was examined for its effect in the prevention of adverse effects caused by gefitinib.