Chemotherapy-Induced Peripheral Neuropathy: Assessment and Treatment Strategies for Advanced Practice Providers

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of numerous anticancer agents. CIPN can persist as chronic pain or sensory symptoms for months to years after discontinuation of the anticancer agent, affecting a patient’s quality of life, function, and morbidity. Although treatment recommendations are limited because of insufficient evidence, many pharmacologic and nonpharmacologic therapies are being explored to prevent and treat CIPN.

At a Glance

• CIPN can affect patients’ morbidity, function, and quality of life.
• Treatment for CIPN varies based on patients’ presentation of sensory, motor, and autonomic symptoms and goals of care to relieve pain or improve function.
• Advanced practice providers can appropriately diagnose and manage the long-term side effects of chemotherapies, such as CIPN, to improve patients’ physical and psychosocial well-being.