Prevention of Bleeding Search Strategy and Results

Initial references prior to update: 13

Databases searched for update: PubMed, CINAHL

Search results of literature retrieved 5/1/2007–1/1/2019:

  • PubMed
    • (hemorrhag* OR haemorrhag* OR bleed* OR blood) AND (mesna OR "Prophylactic platelet transfusion" OR desmopressin OR EACA OR "Gonadotropin Releasing Hormone Agonist" OR "Gonadotropin Releasing Hormone Agonists" OR Lansoprazole OR “Platelet Growth Factor” OR “Platelet Growth Factors” OR “Recombinant Factor” OR “Tranexamic Acid” OR “Transanal Drainage” OR “Rectal Steroid” OR “Rectal Steroids”) AND (Transplant* OR cancer OR neoplasm* OR oncolog* OR chemotherap*)
    • 829 citations retrieved
    • (((MH Hemorrhage -- Prevention and Control OR (TI Blood OR TI bleed*) AND (TI prevent* OR TI stop* OR TI control*))) AND (cancer OR oncolog* OR neoplasm*)
    • 170 citations retrieved

97 titles were selected for a full article review.

51 final studies were included after the removal of duplicates and studies that did not meet inclusion criteria and the addition of manuscripts retrieved in other topics meeting prevention of bleeding-specific criteria.

Inclusion Criteria:

  1. Full research report, systematic review, guideline, or meta-analysis
  2. Study must report results of prevention of bleeding
  3. Study examines an intervention aimed at affecting the prevention of bleeding
  4. Study sample must include patients with cancer
  5. As of 1/1/2016, additional inclusions are (a) sample size of at least 40 or 20 per study group, and (b) for complex interventions, the description of the intervention must be sufficient to identify the components of that intervention.

Exclusion Criteria:

  1. Grey literature
  2. Descriptive studies
  3. Studies that report on the treatment of bleeding