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CNE Article

Associated Toxicities: Assessment and Management Related to CAR T-Cell Therapy

Karen Anderson
Theresa Latchford
CJON 2019, 23(2), 13-19 DOI: 10.1188/19.CJON.S1.13-19
Background: The impressive disease response observed with chimeric antigen receptor (CAR) T-cell therapy is accompanied by the potential for unique and severe toxicities. Cytokine release syndrome (CRS) and neurologic toxicities have emerged as prominent toxicities associated with this treatment...
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CNE Article
Online Exclusive Article

Chlorhexidine Gluconate Baths: Supporting Daily Use to Reduce Central Line–Associated Bloodstream Infections Affecting Immunocompromised Patients

Gladys N. Jusino-Leon
Linda Matheson
Lydia Forsythe
CJON 2019, 23(2), E32-E38 DOI: 10.1188/19.CJON.E32-E38
Background: Chlorhexidine gluconate (CHG) has a broad-spectrum antimicrobial property that has proven to be effective in prolonging skin antisepsis and decreasing pathogens often seen in oncology units. Objectives: The aim was to reduce the incidence of central line–associated bloodstream...
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Essentials

Thrombopoietin Receptor Agonists: Eltrombopag and Romiplostim for the Treatment of Chronic Immune Thrombocytopenia Purpura

Katie Atkinson
CJON 2019, 23(2), 212-216 DOI: 10.1188/19.CJON.212-216
The thrombopoietin receptor agonists, eltrombopag and romiplostim, are second-line agents used to treat chronic immune thrombocytopenia purpura (ITP) in adults and children. ITP is a rare autoimmune disease and hematologic disorder characterized by reduced platelet counts that can result in...
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Supportive Care

Venous Flare Reactions: A Case Report of Reactions Following Etoposide Infusion

Jaya Mini Gill
Janice Frost
Rachelle Park
Marlon Garzo Saria
CJON 2018, 22(6), 597-599 DOI: 10.1188/18.CJON.597-599
Venous flare reaction, a localized allergic response associated with the administration of an irritant, is one of the most common chemotherapy infusion–related reactions. Etoposide, a drug commonly used in patients with lung cancer, has been reported to be an irritant with vesicant properties...
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Article

5-Fluorouracil and Capecitabine: Assessment and Treatment of Uncommon Early-Onset Severe Toxicities Associated With Administration

Edith Brutcher
Deb Christensen
Melissa Hennessey Smith
Judy B. Koutlas
Jean B. Sellers
Tahitia Timmons
Joanna Thompson
CJON 2018, 22(6), 627-634 DOI: 10.1188/18.CJON.627-634
Background: Uncommon early-onset severe toxicities from 5-fluorouracil (5-FU) and capecitabine can be fatal if early warning signs are not recognized and treated promptly. Objectives: This article delineates the differences between expected side effects and uncommon early-onset severe toxicities...
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